Vitiligo is an acquired depigmenting disorder of the skin, in which pigment cells (melanocytes) are lost. It presents with well-defined milky-white patches of skin (leukoderma). Vitiligo affects 0.5â€“1% of the population, and occurs in all races. Males and females are equally affected. Vitiligo is due to loss or destruction of melanocytes, which are the cells that produce melanin.